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XBP1 Recombinant Rabbit Monoclonal Antibody [PSH23-23] (HA724358)

Price: Regular price $385.00

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Catalog# HA724358

Rabbit Monoclonal to XBP1

Tested for

  • WB

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

XBP1 Recombinant Rabbit Monoclonal Antibody [PSH23-23] (HA724358)

Immunogen

Synthetic peptide within human xbp1s aa 327-376.

Host

Rabbit

Positive Control

Huh7 (Human liver cancer cells) cell lysate, Huh7 (Human liver cancer cells) treated with 300nM Thapsigargin for 18 hours cell lysate, C6 (Rat glioma cells) cell lysate, C6 (Rat glioma cells) treated with 300nM Thapsigargin for 18 hours cell lysate.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PSH23-23

APPLICATION DILUTION

  • WB

  • 1:5,000

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 29/40 kDa

Isotype

IgG

TARGET

UNIPROT #

P17861

PROTEIN NAME

XBP1

SYNONYMS

Tax responsive element binding protein 5 antibody;Tax-responsive element-binding protein 5 antibody;TREB5 antibody;X box binding protein 1 antibody;X box binding protein 2 antibody;X-box-binding protein 1 antibody;XBP 1 antibody;XBP-1 antibody;XBP1 antibody;XBP1_HUMAN antibody;XBP2 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Endoplasmic reticulum membrane, Endoplasmic reticulum membrane, Membrane.

FUNCTION

X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular stress response. It was first identified by its ability to bind to the Xbox, a conserved transcriptional element in the promoter of the human leukocyte antigen (HLA) DR alpha. Abnormalities in XBP1 lead to a heightened ER stress and subsequently causes a heightened susceptibility for inflammatory processes that may contribute to Alzheimer's disease. In the colon, XBP1 anomalies have been linked to Crohn's disease.

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