WWOX Recombinant Rabbit Monoclonal Antibody [PSH15-43] (HA723749)

UNIPROT #

Q9NZC7

PROTEIN NAME

WWOX

SYNONYMS

5330426P09Rik antibody;9030416C10Rik antibody;Aberrant WW domain-containing oxidoreductase antibody;D16S432E antibody;EC 1.1.1.- antibody;EIEE28 antibody;FOR antibody;FRA16D antibody;Fragile site FRA16D oxidoreductase antibody;Fragile site FRA16D Oxireductase antibody;HHCMA56 antibody;MGC55975 antibody;PRO0128 antibody;Putative oxidoreductase antibody;SCAR12 antibody;SDR41C1 antibody;Short chain dehydrogenase/reductase family 41C, member 1 antibody;WOX1 antibody;WW domain containing oxidoreductase antibody;WW domain-containing oxidoreductase antibody;WW domain-containing protein WWOX antibody;wwox antibody;WWOX_HUMAN antibody;zgc:55975 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Mitochondrion, Golgi apparatus, Lysosome.

FUNCTION

WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. WWOX is also known as human accelerated region 6. It may, therefore, have played a key role in differentiating humans from apes.