VPS28 Recombinant Rabbit Monoclonal Antibody [JE55-08] (ET7110-94)

UNIPROT #

Q9UK41

PROTEIN NAME

VPS28

SYNONYMS

ESCRT-I complex subunit VPS28 antibody;H-Vps28 antibody;Vacuolar protein sorting 28 antibody;Vacuolar protein sorting 28 (yeast) antibody;Vacuolar protein sorting 28 homolog (S. cerevisiae) antibody;Vacuolar protein sorting 28 homolog antibody;Vacuolar protein sorting-associated protein 28 homolog antibody;VPS 28 antibody;Vps28 antibody;VPS28_HUMAN antibody;Yeast class E protein Vps28p homolog antibody

SEQUENCE SIMILARITIES

Belongs to the VPS28 family.

SUBCELLULAR LOCATION

Late endosome membrane, Cell membrane.

FUNCTION

Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene. This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated protein. The two other subunits of ESCRT-I are vacuolar protein sorting 23 (VPS23), also known as tumor susceptibility gene 101 (TSG101), and vacuolar protein sorting 37 (VPS37). Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally. VPS28 has been shown to interact with TSG101.