VE Cadherin Goat Polyclonal Antibody (IRS212)

PROTEIN NAME

VE Cadherin

SYNONYMS

7B 4 antibody;7B4 antibody;7B4 antigen antibody;CADH5_HUMAN antibody;Cadherin 5 antibody;Cadherin 5 type 2 antibody;Cadherin 5, type 2 (vascular endothelium) antibody;Cadherin 5, type 2, VE cadherin (vascular epithelium) antibody;cadherin, vascular endothelial antibody;cadherin, vascular endothelial, 1 antibody;Cadherin-5 antibody;Cadherin5 antibody;CD 144 antibody;CD144 antibody;CD144 antigen antibody;CDH 5 antibody;CDH5 antibody;CDH5 protein antibody;Endothelial specific cadherin antibody;FLJ17376 antibody;OTTHUMP00000174777 antibody;Vascular endothelial cadherin antibody;Vascular epithelium cadherin antibody;VE Cad antibody;VE-cadherin antibody;VEC antibody

SUBCELLULAR LOCATION

Cell junction, Cell membrane.

FUNCTION

The cadherins are a family of Ca²⁺-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy-terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including β-catenin, to regulate cadherin function. VE-cadherin (for vascular endothelial cadherin, also designated cadherin-5) is localized at intercellular junctions of endothelial cells, where it is thought to play a role in the cohesion and organization of intercellular junctions.