UCP2 Recombinant Rabbit Monoclonal Antibody [PSH19-75] (HA724099)

UNIPROT #

P55851

PROTEIN NAME

UCP2

SYNONYMS

BMIQ4 antibody;Mitochondrial uncoupling protein 2 antibody;SLC25A8 antibody;Solute carrier family 25 member 8 antibody;UCP 2 antibody;ucp2 antibody;UCP2_HUMAN antibody;UCPH antibody;Uncoupling protein 2 antibody;Uncoupling protein 2 mitochondrial proton carrier antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate, or uncouple, oxidative phosphorylation from ATP synthesis by dissipating the mitochondrial membrane potential as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells, which reduces production of reactive oxygen species (ROS). The exact mechanisms of anion transfer by UCPs are not known. UCPs contain the three homologous protein domains of MACPs. Although it was originally thought to play a role in non-shivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species.