UCP1 Recombinant Rabbit Monoclonal Antibody [PSH15-73] (HA723776)

UNIPROT #

P12242

PROTEIN NAME

UCP1

SYNONYMS

mitochondrial brown fat uncoupling protein antibody;Mitochondrial brown fat uncoupling protein 1 antibody;SLC25A7 antibody;Solute carrier family 25 member 7 antibody;Thermogenin antibody;UCP 1 antibody;UCP antibody;UCP1 antibody;UCP1_HUMAN antibody;uncoupling protein 1 (mitochondrial, proton carrier) antibody;Uncoupling protein 1 antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial carrier protein found in brown adipose tissue (BAT). It is used to generate heat by non-shivering thermogenesis, and makes a quantitatively important contribution to countering heat loss in babies which would otherwise occur due to their high surface area-volume ratio. Recent findings indicate that the UCP1 protein plays a crucial role in thermogenesis by catalyzing the dissipative production of heat through protons derived from NADH and FADH2. These electron carriers are produced in the TCA cycle from the oxidation of acetyl-CoA, which comes from the breakdown of free fatty acids. Intriguingly, the acetyl-CoA products undergo a recycling process that facilitates their re-utilization, thereby sustaining the cycle known as the HEAT cycle.