UBE2I Rabbit Polyclonal Antibody (HA500401)

UNIPROT #

P63279

PROTEIN NAME

UBE2I

SYNONYMS

C358B7.1 antibody;p18 antibody;SUMO 1 protein ligase antibody;SUMO conjugating enzyme UBC9 antibody;SUMO-conjugating enzyme UBC9 antibody;SUMO-protein ligase antibody;SUMO1 protein ligase antibody;UBC9 antibody;UBC9_HUMAN antibody;UBCE9 antibody;Ube2i antibody;Ubiquitin carrier protein 9 antibody;Ubiquitin carrier protein antibody;Ubiquitin carrier protein I antibody;Ubiquitin conjugating enzyme 9 antibody;Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9) antibody;Ubiquitin conjugating enzyme E2I (UBC9 homolog, yeast) antibody;Ubiquitin conjugating enzyme UbcE2A antibody;Ubiquitin like protein SUMO 1 conjugating enzyme antibody;Ubiquitin protein ligase E2I antibody;Ubiquitin-conjugating enzyme E2 I antibody;Ubiquitin-protein ligase I antibody

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity. This protein is involved in the pathway protein sumoylation, which is part of Protein modification. Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.