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Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (IRS206RB)

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Catalog# IRS206RB

Rabbit Monoclonal to Tyrosine Hydroxylase

Tested for

  • mIHC

Reacts with

  • Mouse

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (IRS206RB)

Host

Rabbit

Positive Control

Mouse liver tissue, mouse brain tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

APPLICATION DILUTION

  • mIHC

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 58 kDa

Isotype

IgG

TARGET

UNIPROT #

P24529

PROTEIN NAME

Tyrosine Hydroxylase

SYNONYMS

Dystonia 14 antibody;DYT14 antibody;DYT5b antibody;EC 1.14.16.2 antibody;OTTHUMP00000011225 antibody;OTTHUMP00000011226 antibody;ple antibody;Protein Pale antibody;TH antibody;The antibody;TYH antibody;Tyrosine 3 hydroxylase antibody;Tyrosine 3 monooxygenase antibody;Tyrosine 3-hydroxylase antibody;Tyrosine 3-monooxygenase antibody;Tyrosine hydroxylase antibody

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson's disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds.

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