TTF1 Recombinant Rabbit Monoclonal Antibody (IRS063)

UNIPROT #

P50220

PROTEIN NAME

TTF1

SYNONYMS

AV026640 antibody;BCH antibody;Benign chorea antibody;BHC antibody;Homeobox protein NK 2 homolog A antibody;Homeobox protein NK-2 homolog A antibody;Homeobox protein Nkx 2.1 antibody;Homeobox protein Nkx-2.1 antibody;Homeobox protein Nkx2.1 antibody;NK 2 antibody;NK 2 homolog A antibody;NK2 antibody;NK2 homeobox 1 antibody;NK2, drosophila, homolog of, A antibody;NK2.1, mouse, homolog of antibody;Nkx 2 1 antibody;NKX 2.1 antibody;NKX 2A antibody;NKX2 1 antibody;Nkx2-1 antibody;NKX2.1 antibody;NKX21_HUMAN antibody;NKX2A antibody;T EBP antibody;T/EBP antibody;TEBP antibody;Thyroid nuclear factor 1 antibody;Thyroid nuclear factor antibody;Thyroid specific enhancer binding protein antibody;Thyroid transcription factor 1 antibody;Tin man antibody;Tinman antibody;TITF 1 antibody;TITF1 antibody;TTF 1 antibody;TTF-1 antibody;TTF1 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.