TRPV4 Recombinant Rabbit Monoclonal Antibody [PSH16-51] (HA723855)

UNIPROT #

Q9HBA0

PROTEIN NAME

TRPV4

SYNONYMS

BCYM3 antibody;CMT2C antibody;HMSN2C antibody;osm 9 like TRP channel 4 antibody;Osm-9-like TRP channel 4 antibody;OSM9 like transient receptor potential channel 4 antibody;Osmosensitive transient receptor potential channel 4 antibody;OTRPC 4 antibody;OTRPC4 antibody;SMAL antibody;SPSMA antibody;SSQTL1 antibody;Transient receptor potential cation channel subfamily V member 4 antibody;Transient receptor potential protein 12 antibody;TRP 12 antibody;TRP12 antibody;TRPV 4 antibody;TrpV4 antibody;TRPV4_HUMAN antibody;Vanilloid receptor like channel 2 antibody;Vanilloid receptor like protein 2 antibody;Vanilloid receptor related osmotically activated channel antibody;Vanilloid receptor-like channel 2 antibody;Vanilloid receptor-like protein 2 antibody;Vanilloid receptor-related osmotically-activated channel antibody;VR 4 antibody;VR OAC antibody;VR-OAC antibody;VR4 antibody;VRL 2 antibody;VRL-2 antibody;VRL2 antibody;VROAC antibody

SUBCELLULAR LOCATION

Cell membrane, Apical cell membrane, Cell junction, adherens junction, Cell projection, cilium.

FUNCTION

Transient receptor potential cation channel subfamily V member 4 is an ion channel protein that in humans is encoded by the TRPV4 gene. The TRPV4 gene encodes TRPV4, initially named "vanilloid-receptor related osmotically activated channel" (VR-OAC) and "OSM9-like transient receptor potential channel, member 4 (OTRPC4)", a member of the vanilloid subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that has been found involved in multiple physiologic functions, dysfunctions and also disease. It functions in the regulation of systemic osmotic pressure by the brain, in vascular function, in liver, intestinal, renal and bladder function, in skin barrier function and response of the skin to ultraviolet-B radiation, in growth and structural integrity of the skeleton, in function of joints, in airway- and lung function, in retinal and inner ear function, and in pain. The channel is activated by osmotic, mechanical and chemical cues. It also responds to thermal changes (warmth). Channel activation can be sensitized by inflammation and injury.