Transferrin Receptor (CD71) Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JF0956] (HA750333)

UNIPROT #

P02786

PROTEIN NAME

Transferrin Receptor (CD71)

SYNONYMS

CD 71 antibody;CD71 antibody;CD71 antigen antibody;IMD46 antibody;OTTHUMP00000208523 antibody;OTTHUMP00000208524 antibody;OTTHUMP00000208525 antibody;p90 antibody;sTfR antibody;T9 antibody;TFR 1 antibody;TfR antibody;TfR1 antibody;TFR1_HUMAN antibody;TFRC antibody;TR antibody;Transferrin receptor (p90 CD71) antibody;Transferrin receptor protein 1, serum form antibody;Trfr antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M28 family. M28B subfamily.

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.; Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).; Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.

SUBCELLULAR LOCATION

Cell membrane, Melanosome, Secreted.

FUNCTION

CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. CD71 binds to two molecules of transferrin and a serum iron-transport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticulocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregulated upon activation of lymphocytes, monocytes and macrophages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.