Human TNF alpha Recombinant Rabbit Monoclonal Antibody (IRS040)

UNIPROT #

P01375

PROTEIN NAME

TNF alpha

SYNONYMS

APC1 antibody;APC1 protein antibody;Cachectin antibody;DIF antibody;Differentiation inducing factor antibody;Macrophage cytotoxic factor antibody;Tnf antibody;TNF superfamily member 2 antibody;TNF superfamily, member 2 antibody;TNF, macrophage derived antibody;TNF, monocyte derived antibody;TNF-a antibody;TNF-alpha antibody;TNFA antibody;TNFA_HUMAN antibody;TNFSF2 antibody;Tumor necrosis factor (TNF superfamily member 2) antibody;Tumor necrosis factor alpha antibody;Tumor necrosis factor antibody;Tumor necrosis factor ligand superfamily member 2 antibody;Tumor Necrosis Factor, Membrane Form antibody;Tumor necrosis factor, soluble form antibody

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.