TIMP1 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH21-35] (HA751798)

UNIPROT #

P12032

PROTEIN NAME

TIMP1

SYNONYMS

Clgi antibody;Collagenase inhibitor antibody;EPA antibody;EPO antibody;Erythroid Potentiating Activity antibody;Erythroid-potentiating activity antibody;Fibroblast collagenase inhibitor antibody;FLJ90373 antibody;HCI antibody;Human Collagenase Inhibitor antibody;Metalloproteinase inhibitor 1 antibody;Metalloproteinase inhibitor 1 precursor antibody;OTTHUMP00000023214 antibody;TIMP 1 antibody;TIMP antibody;TIMP metallopeptidase inhibitor 1 antibody;TIMP-1 antibody;Timp1 antibody;TIMP1 protein antibody;Tissue Inhibitor of Metalloproteinase 1 antibody;Tissue inhibitor of metalloproteinases 1 antibody;Tissue inhibitor of metalloproteinases antibody;Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.