THP Rabbit Polyclonal Antibody (HA500553)

UNIPROT #

P07911

PROTEIN NAME

THP

SYNONYMS

ADMCKD2 antibody;FJHN antibody;HNFJ antibody;HNFJ1 antibody;MCKD2 antibody;medullary cystic kidney disease 2 (autosomal dominant) antibody;Tamm Horsfall glycoprotein antibody;Tamm Horsfall urinary glycoprotein antibody;Tamm-Horsfall urinary glycoprotein antibody;THGP antibody;THP antibody;Umod antibody;Urehd1 antibody;urehr4 antibody;UROM_HUMAN antibody;uromodulin (uromucoid, Tamm-Horsfall glycoprotein) antibody;Uromodulin antibody;Uromodulin, secreted form antibody;Uromucoid antibody

SUBCELLULAR LOCATION

Apical cell membrane, Basolateral cell membrane, Cell projection, cilium membrane, Secreted.

FUNCTION

Uromodulin (UMOD), also known as Tamm–Horsfall protein (THP), is a zona pellucida-like domain-containing glycoprotein that in humans is encoded by the UMOD gene. Uromodulin is the most abundant protein excreted in ordinary urine. THP is a GPI-anchored glycoprotein. It is not derived from blood plasma but is produced by the thick ascending limb of the loop of Henle of the mammalian kidney. While the monomeric molecule has a MW of approximately 85 kDa, it is physiologically present in urine in large aggregates of up to several million Da. When this protein is concentrated at low pH, it forms a gel. Uromodulin represents the most abundant protein in normal human urine (results based on MSMS determinations). It is the matrix of urinary casts derived from the secretion of renal tubular cells.