TGF beta 1 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PD00-17] (HA750485)

UNIPROT #

P01137

PROTEIN NAME

TGF beta 1

SYNONYMS

Cartilage-inducing factor antibody;CED antibody;Differentiation inhibiting factor antibody;DPD1 antibody;LAP antibody;Latency-associated peptide antibody;Prepro transforming growth factor beta 1 antibody;TGF beta 1 antibody;TGF beta antibody;TGF beta 1 protein antibody;TGF-beta 1 protein antibody;TGF-beta-1 antibody;TGF-beta-5 antibody;TGF-beta1 antibody;TGFB antibody;Tgfb-1 antibody;tgfb1 antibody;TGFB1_HUMAN antibody;TGFbeta antibody;TGFbeta1 antibody;Transforming Growth Factor b1 antibody;Transforming Growth Factor beta 1 antibody;Transforming growth factor beta 1a antibody;transforming growth factor beta-1 antibody;transforming growth factor, beta 1 antibody;Transforming Growth Factor-ß1 antibody

SUBCELLULAR LOCATION

Extracellular matrix, Secreted.

FUNCTION

Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene. TGF-β is a multifunctional set of peptides that controls proliferation, differentiation, and other functions in many cell types. TGF-β acts synergistically with transforming growth factor-alpha (TGF-α) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGF-β activation and signaling may result in apoptosis. Many cells synthesize TGF-β and almost all of them have specific receptors for this peptide. TGF-β1, TGF-β2, and TGF-β3 all function through the same receptor signaling systems. TGF-β1 was first identified in human platelets as a protein with a molecular mass of 25 kilodaltons with a potential role in wound healing. It was later characterized as a large protein precursor (containing 390 amino acids) that was proteolytically processed to produce a mature peptide of 112 amino acids. TGF-β1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGF-β1.