TDG Recombinant Rabbit Monoclonal Antibody [PSH10-11] (HA723180)

UNIPROT #

Q13569

PROTEIN NAME

TDG

SYNONYMS

C JUN leucine zipper interactive protein antibody;C JUN leucine zipper interactive protein antibody;C-JUN leucine zipper interactive protein JZA-3 antibody;E130317C12Rik antibody;EC 3.2.2.29 antibody;G/T mismatch specific thymine DNA glycosylase antibody;G/T mismatch specific thymine DNA glycosylase antibody;G/T mismatch-specific thymine DNA glycosylase antibody;JZA 3 antibody;Jza1 antibody;T:G mismatch thymine glycosylase antibody;Tdg antibody;TDG_HUMAN antibody;Thymine DNA glycosylase antibody;Thymine-DNA glycosylase antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. Several bacterial proteins have strong sequence homology with this protein. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. TDG knockout mouse models showed no increase in mispairing frequency suggesting that other enzymes, like the functional homologue MBD4, may provide functional redundancy. This gene may have a pseudogene in the p arm of chromosome 12.