TAPA1/CD81 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SN206-01] (HA751848)

UNIPROT #

P60033

PROTEIN NAME

TAPA1/CD81

SYNONYMS

26 kDa cell surface protein TAPA 1 antibody;26 kDa cell surface protein TAPA-1 antibody;26 kDa cell surface protein TAPA1 antibody;CD 81 antibody;CD81 antibody;CD81 antigen (target of antiproliferative antibody;1) antibody;CD81 antigen antibody;CD81 molecule antibody;CD81_HUMAN antibody;CVID6 antibody;S5.7 antibody;TAPA 1 antibody;TAPA1 antibody;Target of the antiproliferative antibody;1 antibody;Tetraspanin 28 antibody;Tetraspanin-28 antibody;Tetraspanin28 antibody;Tspan 28 antibody;Tspan-28 antibody;Tspan28 antibody

SEQUENCE SIMILARITIES

Belongs to the tetraspanin (TM4SF) family.

TISSUE SPECIFICITY

Expressed on B cells (at protein level). Expressed in hepatocytes (at protein level). Expressed in monocytes/macrophages (at protein level). Expressed on both naive and memory CD4-positive T cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Not glycosylated.; Likely constitutively palmitoylated at low levels. Protein palmitoylation is up-regulated upon coligation of BCR and CD9-C2R-CD81 complexes in lipid rafts.

SUBCELLULAR LOCATION

Cell membrane, Basolateral cell membrane.

FUNCTION

CD81, also called TAPA-1, is a type III transmembrane protein that is broadly expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. CD81 is believed to be involved in both cell growth and signal transduction. It can be present as a multimolecular complex in association with CD37 and/or CD53, or on the surface of B cells in association with CD19, CD21 and/or MHC class II antigens.