TAP2 Recombinant Rabbit Monoclonal Antibody [PSH16-55] (HA723859)

UNIPROT #

Q03519

PROTEIN NAME

TAP2

SYNONYMS

ABC transporter, MHC 2 antibody;ABC18 antibody;ABCB3 antibody;Antigen peptide transporter 2 antibody;APT2 antibody;ATP binding cassette, sub family B (MDR/TAP), member 3 antibody;ATP-binding cassette sub-family B member 3 antibody;D6S217E antibody;Peptide supply factor 2 antibody;Peptide transporter involved in antigen processing 2 antibody;Peptide transporter PSF2 antibody;Peptide transporter TAP2 antibody;PSF 2 antibody;PSF-2 antibody;PSF2 antibody;Really interesting new gene 11 protein antibody;RING 11 antibody;RING11 antibody;TAP 2 antibody;Tap2 antibody;TAP2_HUMAN antibody;Transporter 2 ATP binding cassette sub family B antibody;Transporter 2, ABC (ATP binding cassette antibody;Transporter 2, ATP binding cassette, sub family B (MDR/TAP) antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.