T-bet / Tbx21 Recombinant Rabbit Monoclonal Antibody [PSH23-00] (HA724339)

UNIPROT #

Q9UL17

PROTEIN NAME

T-bet / Tbx21

SYNONYMS

T bet antibody;T box 21 antibody;T box expressed in T cells antibody;T box protein 21 antibody;T box transcription factor TBX21 antibody;T cell specific T box transcription factor antibody;T cell specific T box transcription factor T bet antibody;T PET antibody;T-box protein 21 antibody;T-box transcription factor TBX21 antibody;T-cell-specific T-box transcription factor T-bet antibody;TBET antibody;TBLYM antibody;TBX 21 antibody;Tbx21 antibody;TBX21_HUMAN antibody;TPET antibody;Transcription factor TBLYM antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells), is a protein that in humans is encoded by the TBX21 gene. Though being for long thought of only as a master regulator of type 1 immune response, T-bet has recently been shown to be implicated in development of various immune cell subsets and maintenance of mucosal homeostasis. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNg). Expression of the human ortholog also correlates with IFNg expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.