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SV2A Recombinant Antibody [PSH10-69] - Rat IgG1 (Chimeric) (HA601421)

Price: Regular price $315.00

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Catalog# HA601421

to SV2A

Tested for

  • IHC-Fr

  • IHC-P

  • WB

Reacts with

  • Mouse

  • Rat

  • Cynomolgus monkey

  • Pig

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Chimeric Antibody primary

Product Name

SV2A Recombinant Antibody [PSH10-69] - Rat IgG1 (Chimeric) (HA601421)

Immunogen

Recombinant protein within n terminal human sv2a.

Positive Control

Mouse cerebellum tissue, mouse pancreas tissue, rat cerebellum tissue, Mouse brain tissue lysate, Rat brain tissue lysate.

Conjugation

Unconjugated

Clone Number

PSH10-69

APPLICATION DILUTION

  • IHC-Fr

  • 1:500

  • IHC-P

  • 1:200-1:500

  • WB

  • 1:5,000

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4C. Store at +4C short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20C long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 83 kDa

TARGET

UNIPROT #

Q9JIS5

PROTEIN NAME

SV2A

SYNONYMS

KIAA0736 antibody;OTTHUMP00000014065 antibody;SV2 antibody;Sv2a antibody;SV2A_HUMAN antibody;Synaptic vesicle glycoprotein 2 antibody;Synaptic vesicle glycoprotein 2A antibody;Synaptic vesicle protein 2a antibody

SUBCELLULAR LOCATION

Presynapse, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane.

FUNCTION

Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein belonging to a family of keratan sulfate proteoglycans, located on the synaptic vesicles of mammalian neuronal and endocrine cells. It's encoded by the SV2A gene. SV2A is the most widely expressed isoform of the SV2 family (which also includes the SV2B and SV2C proteins) found in all brain regions. The role of the SV2 proteins is not well understood, however they are thought to be involved in regulating vesicular processes. The SV2A protein is a target of the anti-epileptic drugs (anticonvulsants) levetiracetam and brivaracetam but it is not clear how these drug affect SV2A activity.

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