Survivin Recombinant Rabbit Monoclonal Antibody [PSH11-73] (HA723369)

UNIPROT #

O15392

PROTEIN NAME

Survivin

SYNONYMS

API4 antibody;Apoptosis inhibitor 4 antibody;Apoptosis inhibitor survivin antibody;Apoptosis inhibitor4 antibody;Baculoviral IAP repeat containing 5 antibody;Baculoviral IAP repeat containing protein 5 antibody;Baculoviral IAP repeat-containing protein 5 antibody;BIRC 5 antibody;BIRC5 antibody;BIRC5_HUMAN antibody;EPR 1 antibody;IAP4 antibody;Survivin variant 3 alpha antibody;SVV antibody;TIAP antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Chromosome, centromere, cytoskeleton, spindle, kinetochore, Midbody.

FUNCTION

Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in tumour growth. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells. These data suggest survivin might provide a new target for cancer therapy that would discriminate between transformed and normal cells. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that Survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. The molecular mechanisms of survivin regulation are still not well understood, but regulation of survivin seems to be linked to the p53 protein. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.