SUMO-1 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SJ20-03] (HA750110)

UNIPROT #

P63165

PROTEIN NAME

SUMO-1

SYNONYMS

DAP1 antibody;GAP modifying protein 1 antibody;GAP-modifying protein 1 antibody;GMP 1 antibody;GMP1 antibody;OFC10 antibody;PIC 1 antibody;PIC1 antibody;SENP2 antibody;Sentrin 1 antibody;Sentrin antibody;Small ubiquitin related modifier 1 antibody;Small ubiquitin-like modifier 1 antibody;Small ubiquitin-related modifier 1 antibody;SMT3 antibody;SMT3 homolog 3 antibody;SMT3 suppressor of mif two 3 homolog 1 antibody;SMT3, yeast, homolog 3 antibody;Smt3C antibody;SMT3H3 antibody;SUMO-1 antibody;SUMO1 antibody;SUMO1_HUMAN antibody;Ubiquitin homology domain protein PIC1 antibody;Ubiquitin Like 1 antibody;Ubiquitin like protein SMT3C antibody;Ubiquitin like protein UBL1 antibody;Ubiquitin-homology domain protein PIC1 antibody;Ubiquitin-like protein SMT3C antibody;Ubiquitin-like protein UBL1 antibody;UBL 1 antibody;UBL1 antibody

SEQUENCE SIMILARITIES

Belongs to the ubiquitin family. SUMO subfamily.

POST-TRANSLATIONAL MODIFICATION

Cleavage of precursor form by SENP1 or SENP2 is necessary for function.; Polymeric SUMO1 chains undergo polyubiquitination by RNF4.

SUBCELLULAR LOCATION

Nucleus membrane, Cytoplasm, Nucleus, Cell membrane.

FUNCTION

The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease.