SSBP1 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH21-31] (HA751794)

UNIPROT #

Q04837

PROTEIN NAME

SSBP1

SYNONYMS

Single-stranded DNA-binding protein, mitochondrial antibody;Mt SSB antibody;Mt-SSB antibody;MtSSB antibody;PWP1 interacting protein 17 antibody;PWP1-interacting protein 17 antibody;SENSOR OF SINGLE-STRANDED DNA COMPLEX antibody;Single stranded DNA binding protein 1 antibody;Single stranded DNA binding protein antibody;Single stranded DNA binding protein mitochondrial antibody;Single-stranded DNA-binding protein antibody;SOSS B1 antibody;SOSS COMPLEX SUBUNIT B1 antibody;SSBP 1 antibody;SSBP antibody;SSBP_HUMAN antibody;SSBP1 antibody

SUBCELLULAR LOCATION

Mitochondrion, Mitochondrion matrix, mitochondrion nucleoid.

FUNCTION

Single-stranded DNA-binding protein, mitochondrial is a protein that in humans is encoded by the SSBP1 gene. SSBP 1 is a housekeeping gene involved in mitochondrial biogenesis. Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) . In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair.