SOD2 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JJ089-02] (HA750314)

UNIPROT #

P04179

PROTEIN NAME

SOD2

SYNONYMS

Indophenoloxidase B antibody;IPO B antibody;IPOB antibody;Manganese containing superoxide dismutase antibody;Manganese SOD antibody;Manganese superoxide dismutase antibody;Mangano superoxide dismutase antibody;Mn SOD antibody;Mn superoxide dismutase antibody;MNSOD antibody;MVCD6 antibody;SOD 2 antibody;SOD2 antibody;SODM_HUMAN antibody;Superoxide dismutase [Mn] mitochondrial antibody;Superoxide dismutase [Mn], mitochondrial antibody;Superoxide dismutase 2 mitochondrial antibody

SEQUENCE SIMILARITIES

Belongs to the iron/manganese superoxide dismutase family.

POST-TRANSLATIONAL MODIFICATION

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.; Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).; Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.

SUBCELLULAR LOCATION

Mitochondrion matrix.

FUNCTION

The superoxide dismutase family is composed of three metalloenzymes (SOD-1, SOD-2 and SOD-3) that catalyze the oxido-reduction of reactive oxygen species (ROS) such as superoxide anion. The SOD-2 precursor is a 222 amino acid protein that is encoded by nuclear chromatin, synthesized in the cytosol and imported posttranslationally into the mitochondrial matrix. Unlike SOD-1, which is a homodimeric cytosolic Cu-Zn enzyme, SOD-2 is a homotetrameric manganese enzyme (also known as MnSOD) that functions in the mitochondrion. ROS are implicated in a wide range of degenerative processes, including Alzheimer’s disease, Parkinson’s disease and ischemic heart disease. Homozygous mutant mice, which lack SOD-2, exhibit dilated cardiomyopathy, accumulation of lipid in liver and skeletal muscle, metabolic acidosis, oxidative DNA damage and respiratory chain deficiencies in heart and skeletal muscle. Polymorphisms in the SOD-2 gene have also been implicated in nonfamilial, idiopathic, dilated cardiomyopathy in humans.