SLP76 Recombinant Rabbit Monoclonal Antibody [PSH09-22] (HA723080)

UNIPROT #

Q13094

PROTEIN NAME

SLP76

SYNONYMS

CG8697 antibody;LCP 2 antibody;LCP2 antibody;LCP2_HUMAN antibody;Lymphocyte cytosolic protein 2 antibody;SH2 domain containing leukocyte protein 76 KD antibody;SH2 domain containing leukocyte protein of 76kD antibody;SH2 domain containing leukocyte protein of 76kDa antibody;SH2 domain-containing leukocyte protein of 76 kDa antibody;SLP 76 antibody;SLP 76 tyrosine phosphoprotein antibody;SLP-76 antibody;SLP-76 tyrosine phosphoprotein antibody;SLP76 antibody;SLP76 tyrosine phosphoprotein antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa), also known as LCP2 or SLP-76, is a signal-transducing adaptor protein expressed in T cells and myeloid cells and is important in the signaling of T-cell receptors (TCRs). As an adaptor protein, SLP-76 does not have catalytic functions, primarily binding other signaling proteins to form larger signaling complexes. It is a key component of the signaling pathways of receptors with immunoreceptor tyrosine-based activation motifs (ITAMs) such as T-cell receptors, its precursors, and receptors for the Fc regions of certain antibodies.SLP-76 is expressed in T-cells and related lymphocytes like natural killer cells.