SLC31A1 / CTR1 Recombinant Rabbit Monoclonal Antibody [PSH09-67] (HA723132)

UNIPROT #

O15431

PROTEIN NAME

SLC31A1 / CTR1

SYNONYMS

Copper transport 1 homolog antibody;Copper transporter 1 antibody;COPT1 antibody;COPT1_HUMAN antibody;CTR1 antibody;hCTR1 antibody;High affinity copper uptake protein 1 antibody;SLC31A1 antibody;solute carrier family 31 (copper tansporters) member 1 antibody;Solute carrier family 31 member 1 antibody

SUBCELLULAR LOCATION

Cell membrane ; Early endosome membrane ; Recycling endosome membrane ; Apical cell membrane ; Late endosome membrane ; Basolateral cell membrane.

FUNCTION

High affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene.Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and intracellular compartmentalization or buffering of copper strictly regulated. The 2 related genes ATP7A and ATP7B, responsible for the human diseases Menkes syndrome and Wilson disease, respectively, are involved in copper export. In S. cerevisiae, the copper uptake genes CTR1, CTR2, and CTR3 have been identified, and in human the CTR1 and CTR2 (MIM 603088) genes have been identified.