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SLC12A3 Recombinant Rabbit Monoclonal Antibody [PSH24-16] (HA724427)

Price: Regular price $385.00

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Catalog# HA724427

Rabbit Monoclonal to SLC12A3

Tested for

  • WB

  • IHC-Fr

  • IHC-P

  • IP

Reacts with

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

SLC12A3 Recombinant Rabbit Monoclonal Antibody [PSH24-16] (HA724427)

Immunogen

Recombinant protein within mouse slc12a3 aa 1-133.

Host

Rabbit

Positive Control

Mouse kidney (Unboiled) tissue lysate, Rat kidney (Unboiled) tissue lysate.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PSH24-16

APPLICATION DILUTION

  • WB

  • 1:5,000

  • IHC-Fr

  • 1:1,000

  • IHC-P

  • 1:90,000

  • IP

  • 1-2μg/sample

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 111 kDa

Isotype

IgG

TARGET

UNIPROT #

P59158

PROTEIN NAME

SLC12A3

SYNONYMS

Solute carrier family 12 member 3;Na-Cl symporter;Thiazide-sensitive sodium-chloride cotransporter;Slc12a3;Ncc;Tsc

SUBCELLULAR LOCATION

Cell membrane, Apical cell membrane.

FUNCTION

The sodium-chloride symporter (also known as Na+-Cl− cotransporter, NCC or NCCT, or as the thiazide-sensitive Na+-Cl− cotransporter or TSC) is a cotransporter in the kidney which has the function of reabsorbing sodium and chloride ions from the tubular fluid into the cells of the distal convoluted tubule of the nephron. It is a member of the SLC12 cotransporter family of electroneutral cation-coupled chloride cotransporters. In humans, it is encoded by the SLC12A3 gene (solute carrier family 12 member 3) located in 16q13. A loss of NCC function causes Gitelman syndrome, an autosomic recessive disease characterized by salt wasting and low blood pressure, hypokalemic metabolic alkalosis, hypomagnesemia and hypocalciuria. Over a hundred different mutations in the NCC gene have been identified.

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