SKP2 Rabbit Polyclonal Antibody (HA500427)

UNIPROT #

Q13309

PROTEIN NAME

Skp2

SYNONYMS

CDK2/Cyclin A associated protein p45 antibody;Cyclin A/CDK2 associated protein p45 antibody;Cyclin-A/CDK2-associated protein p45 antibody;F box protein Skp2 antibody;F box/LRR repeat protein 1 antibody;F-box protein Skp2 antibody;F-box/LRR-repeat protein 1 antibody;FBL 1 antibody;FBL1 antibody;FBXL 1 antibody;FBXL1 antibody;FLB 1 antibody;FLB1 antibody;MGC1366 antibody;p45 antibody;p45skp2 antibody;S phase kinase associated protein 2 (p45) antibody;S phase kinase associated protein 2 antibody;S-phase kinase-associated protein 2 antibody;S-phase kinase-associated protein 2 E3 ubiquitin protein ligase antibody;SKP 2 antibody;Skp2 antibody;SKP2_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene. Skp2 contains 424 residues in total with the ~40 amino acid F-box domain lying closer to the N-terminal region at the 94-140 position and the C-terminal region forming a concave surface consisting of ten leucine-rich repeats (LRRs). The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which often—but not always—recognize substrates in a phosphorylation-dependent manner. In this SCF complex, Skp2 acts as the substrate recognition factor.