Siglec 8 Recombinant Mouse Monoclonal Antibody - BSA and Azide free [PSH19-67] (HA601584)

UNIPROT #

Q9NYZ4

PROTEIN NAME

Siglec 8

SYNONYMS

CD329 antigen antibody;CDw329 antibody;SAF 2 antibody;SAF-2 antibody;SAF2 antibody;Sialic acid binding Ig like lectin 8 antibody;Sialic acid-binding Ig-like lectin 8 antibody;Sialoadhesin family member 2 antibody;SIGL8_HUMAN antibody;Siglec 8 antibody;Siglec-8 antibody;SIGLEC8 antibody;SIGLEC8L antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Sialic acid-binding Ig-like lectin 8 is a protein that in humans is encoded by the SIGLEC8 gene. This gene is located on chromosome 19q13.4, about 330 kb downstream of the SIGLEC9 gene. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Due to its high level of sequence homology with CD33 (Siglec-3), Siglec-8 is grouped within the CD33-related siglec subfamily. This family is composed of a rapidly evolving group of siglecs that share 50–99% sequence identity. Most members of the subfamily also possess conserved cytoplasmic ITIM and ITIM-like sequences.