SCO2 Recombinant Rabbit Monoclonal Antibody [PSH09-97] (HA723166)

UNIPROT #

O43819

PROTEIN NAME

SCO2

SYNONYMS

Cytochrome oxidase deficient homolog 2 antibody;MGC125823 antibody;MGC125825 antibody;OTTHUMP00000196774 antibody;OTTHUMP00000196775 antibody;Protein SCO2 homolog, mitochondrial antibody;SCO (cytochrome oxidase deficient, yeast) homolog 2 antibody;SCO 1L antibody;SCO 2 antibody;SCO cytochrome oxidase deficient homolog 2 (yeast) antibody;SCO cytochrome oxidase deficient homolog 2 antibody;SCO1L antibody;SCO2 antibody;SCO2_HUMAN antibody;Synthesis of cytochrome c oxidase 2 antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

The SCO2 gene encodes for a protein essential for the assembly and function of Mammalian cytochrome c oxidase (COX)(Complex IV) of the mitochondrial respiratory chain. SCO2 acts as a metallochaperone involved in the biogenesis of cytochrome c oxidase subunit II, an essential subunit of Complex IV which transfers the electrons from cytochrome c to the bimetallic center of the catalytic subunit 1 via its binuclear copper A center. The biogenesis involves the transport of copper to the Cu(A) site on the cytochrome c oxidase subunit II leading to the proper synthesis and maturation of the subunit. In addition, SCO2 acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of the cytochrome c oxidase subunit II. The maturation and synthesis of cytochrome c oxidase subunit II is required for the function of Mammalian cytochrome c oxidase (COX)(Complex IV).Complex IV, a multimeric protein complex that requires several assembly factors, catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane