S100A9 Recombinant Rabbit Monoclonal Antibody (IRS039)

UNIPROT #

P06702

PROTEIN NAME

S100A9

SYNONYMS

Leukocyte L1 complex heavy chain antibody;60B8AG antibody;CAGB antibody;Calgranulin B antibody;Calgranulin-B antibody;Calprotectin L1H subunit antibody;CFAG antibody;CGLB antibody;Cystic fibrosis antigen B antibody;L1AG antibody;Leukocyte L1 complex heavy chain antibody;LIAG antibody;MAC387 antibody;MIF antibody;Migration inhibitory factor related protein 14 antibody;Migration inhibitory factor-related protein 14 antibody;MRP 14 antibody;MRP-14 antibody;MRP14 antibody;Myeloid-related protein 14 antibody;NIF antibody;OTTHUMP00000015331 antibody;p14 antibody;Protein S100-A9 antibody;S100 A9 antibody;S100 calcium binding protein A9 antibody;S100 calcium binding protein A9 calgranulin B antibody;S100 calcium-binding protein A9 antibody;S100A9 antibody;S10A9_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the S-100 family.

TISSUE SPECIFICITY

Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated. Phosphorylation inhibits activation of tubulin polymerization.; S-nitrosylation of Cys-3 is implicated in LDL(ox)-induced S-nitrosylation of GAPDH at 'Cys-247' through a transnitrosylase mechanism involving a iNOS-S100A8/9 complex.

SUBCELLULAR LOCATION

Secreted, Cytoplasm, Cell membrane.

FUNCTION

The family of EF-hand type Ca²⁺-binding proteins includes Calbindin (previously designated vitamin D-dependent Ca²⁺-binding protein), S-100α and β, Calgranulin A (also designated MRP8), Calgranulin B (also designated MRP14) and Calgranulin C (S-100 like protein), and the parvalbumin family members, including parvalbumin α and parvalbumin β (also designated oncomodulin). Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100α and β are present in a variety of other tissues, and Calbindin is present in intestine and kidney. Parvalbumin α is also found in fast-contracting/relaxing skeletal muscle fibers and parvalbumin β is found in many tumor tissues as well as in the organ of Corti. Calbindin, S-100 proteins and parvalbulmins have all been detected in leydig cells and testis. These proteins are thought to play a role in hormone production and spermatogenesis. Calgranulin is expressed in macrophages and epithelial cells.