S100 beta Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SC57-02] (HA750209)

UNIPROT #

P04271

PROTEIN NAME

S100 beta

SYNONYMS

NEF antibody;Protein S100 B antibody;Protein S100-B antibody;S 100 calcium binding protein beta chain antibody;S 100 protein beta chain antibody;S-100 protein beta chain antibody;S-100 protein subunit beta antibody;S100 antibody;S100 calcium binding protein beta (neural) antibody;S100 calcium-binding protein B antibody;S100 protein beta chain antibody;S100B antibody;S100B_HUMAN antibody;S100beta antibody

SEQUENCE SIMILARITIES

Belongs to the S-100 family.

TISSUE SPECIFICITY

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Secreted.

FUNCTION

S100 calcium-binding protein B (S100B) is a protein of the S100 protein family. S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B is glial-specific and is expressed primarily by astrocytes, but not all astrocytes express S100B. It has been shown that S100B is only expressed by a subtype of mature astrocytes that ensheath blood vessels and by NG2-expressing cells. This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing CNS it acts as a neurotrophic factor and neuronal survival protein. In the adult organism it is usually elevated due to nervous system damage, which makes it a potential clinical marker.