Ryanodine receptor 2 / RYR-2 Recombinant Rabbit Monoclonal Antibody [PSH15-54] (HA723760)

UNIPROT #

E9Q401

PROTEIN NAME

Ryanodine receptor 2 / RYR-2

SYNONYMS

ARVC2 antibody;ARVD2 antibody;Cardiac muscle ryanodine receptor antibody;Cardiac muscle ryanodine receptor-calcium release channel antibody;hRYR-2 antibody;ryanodine receptor 2 (cardiac) antibody;Ryanodine receptor 2 antibody;RyR antibody;RYR-2 antibody;RyR2 antibody;RYR2_HUMAN antibody;Type 2 ryanodine receptor antibody;VTSIP antibody

SUBCELLULAR LOCATION

Sarcoplasmic reticulum membrane.

FUNCTION

Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. In the process of cardiac calcium-induced calcium release, RYR2 is the major mediator for sarcoplasmic release of stored calcium ions. The RYR2 protein functions as the major component of a calcium channel located in the sarcoplasmic reticulum that supplies ions to the cardiac muscle during systole. To enable cardiac muscle contraction, calcium influx through voltage-gated L-type calcium channels in the plasma membrane allows calcium ions to bind to RYR2 located on the sarcoplasmic reticulum. This binding causes the release of calcium through RYR2 from the sarcoplasmic reticulum into the cytosol, where it binds to the C domain of troponin, which shifts tropomyosin and allows the myosin ATPase to bind to actin, enabling cardiac muscle contraction. RYR2 channels are associated with many cellular functions, including mitochondrial metabolism, gene expression and cell survival, in addition to their role in cardiomyocyte contraction.