RIP3 Recombinant Rabbit Monoclonal Antibody [PSH23-11] (HA724351)

UNIPROT #

Q9QZL0

PROTEIN NAME

RIP3

SYNONYMS

Receptor interacting protein 3 antibody;Receptor interacting serine threonine kinase 3 antibody;Receptor interacting serine/threonine protein kinase 3 antibody;Receptor-interacting protein 3 antibody;Receptor-interacting serine/threonine-protein kinase 3 antibody;RIP 3 antibody;RIP like protein kinase 3 antibody;RIP-3 antibody;RIP-like protein kinase 3 antibody;RIPK 3 antibody;RIPK3 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Nucleus.

FUNCTION

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.