RBP4 Recombinant Rabbit Monoclonal Antibody [PSH16-97] (HA723893)

UNIPROT #

P02753

PROTEIN NAME

RBP4

SYNONYMS

OTTHUMP00000020114 antibody;OTTHUMP00000020115 antibody;OTTHUMP00000020116 antibody;Plasma retinol binding protein 4 antibody;Plasma retinol-binding protein antibody;Plasma retinol-binding protein(1-176) antibody;PRBP antibody;PRO2222 antibody;RBP antibody;RBP4 antibody;RDCCAS antibody;RET4_HUMAN antibody;Retinol binding protein 4 antibody;Retinol binding protein 4 interstitial antibody;Retinol binding protein 4 plasma antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Retinol binding protein 4, also known as RBP4, is a transporter protein for retinol (vitamin A alcohol). RBP4 has a molecular weight of approximately 21 kDa and is encoded by the RBP4 gene in humans. It is mainly, though not exclusively, synthesized in the liver and circulates in the bloodstream as a hepatokine bound to retinol in a complex with transthyretin. RBP4 has been a drug target for ophthalmology research due to its role in vision. RBP4 may also be involved in metabolic diseases as suggested by recent studies. This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.