RBM15B Mouse Monoclonal Antibody [A10D12+A10D11] (HA601308)

UNIPROT #

Q8NDT2

PROTEIN NAME

RBM15B

SYNONYMS

1810017N16Rik antibody;Chromosome 3p21.1 gene sequence antibody;HUMAGCGB antibody;huOTT3 antibody;One twenty two protein 3 antibody;One-twenty two protein 3 antibody;OTT3 antibody;Putative RNA binding protein 15B antibody;Putative RNA-binding protein 15B antibody;RB15B_HUMAN antibody;RBM15B antibody;RGD1305937 antibody;RNA binding motif protein 15B antibody;RNA-binding motif protein 15B antibody

SUBCELLULAR LOCATION

Nucleus, nucleoplasm, Nucleus speckle, Nucleus envelope.

FUNCTION

RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1.