Rbm15 Mouse Monoclonal Antibody [A10H4] (HA601347)

UNIPROT #

Q96T37

PROTEIN NAME

Rbm15

SYNONYMS

One twenty two protein antibody;One-twenty two protein 1 antibody;OTT antibody;OTT1 antibody;Putative RNA-binding protein 15 antibody;RBM15 antibody;RBM15_HUMAN antibody;RNA binding motif protein 15 antibody;RNA-binding motif protein 15 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation.