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Mouse/Rat RAGE Recombinant Rabbit Monoclonal Antibody - BSA and Azide free (Detector) [PSH24-86] (HA724481)

Price: Regular price $649.00

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Catalog# HA724481

Rabbit Monoclonal to RAGE

Tested for

  • ELISA(Det)

Reacts with

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Mouse/Rat RAGE Recombinant Rabbit Monoclonal Antibody - BSA and Azide free (Detector) [PSH24-86] (HA724481)

Immunogen

Recombinant protein within mouse rage aa 23-342 (ha211241).

Host

Rabbit

Positive Control

Recombinant Mouse RAGE protein (HA211241).

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PSH24-86

APPLICATION DILUTION

  • ELISA(Det)

  • Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH24-85] to Mouse/Rat RAGE (Capture) (HA724480) and Recombinant Mouse RAGE protein (HA211241) as the standard. The reference range value is 7.8-2,000 pg/mL.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4).

Concentration

1ug/ul

Purification

Protein A affinity purified.

Isotype

IgG

TARGET

UNIPROT #

Q62151

PROTEIN NAME

RAGE

SYNONYMS

Advanced glycosylation end product-specific receptor antibody;Ager antibody;MGC2235 antibody;Receptor for advanced glycosylation end products antibody

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions, including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 ras and MAP kinase, which leads to activation of transcription.

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