PUMA Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SR42-09] (HA750038)

UNIPROT #

Q9BXH1

PROTEIN NAME

PUMA

SYNONYMS

BBC 3 antibody;Bbc3 antibody;BBC3_HUMAN antibody;BCL 2 binding component 3 antibody;Bcl-2-binding component 3 antibody;BCL2 binding component 3 antibody;JFY 1 antibody;JFY-1 antibody;JFY1 antibody;p53 up regulated modulator of apoptosis antibody;p53 up-regulated modulator of apoptosis antibody;p53 Upregulated Modulator of Apoptosis antibody;PUMA alpha antibody;PUMA/JFY1 antibody

SEQUENCE SIMILARITIES

Belongs to the Bcl-2 family.

TISSUE SPECIFICITY

Ubiquitously expressed.

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. The expression of PUMA is regulated by the tumor suppressor p53. PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. After activation, PUMA interacts with antiapoptotic Bcl-2 family members, thus freeing Bax and/or Bak which are then able to signal apoptosis to the mitochondria. Following mitochondrial dysfunction, the caspase cascade is activated ultimately leading to cell death.