PSGL-1 Recombinant Rabbit Monoclonal Antibody [PSH20-00] (HA724120)

UNIPROT #

Q62170

PROTEIN NAME

PSGL-1

SYNONYMS

CD 162 antibody;CD162 antibody;CD162 antigen antibody;CLA antibody;Cutaneous lymphocyte associated associated antigen antibody;P selectin glycoprotein ligand 1 antibody;P selectin glycoprotein ligand 1 precursor antibody;P-selectin glycoprotein ligand 1 antibody;PSGL 1 antibody;PSGL-1 antibody;PSGL1 antibody;Selectin P ligand antibody;SELPLG antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

PSGL-1 is expressed on all white blood cells and plays an important role in the recruitment of white blood cells into inflamed tissue: White blood cells normally do not interact with the endothelium of blood vessels. However, inflammation causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood vessel wall. White blood cells present in flowing blood can interact with CAM. The first step in this interaction process is carried out by PSGL-1 interacting with P-selectin and/or E-selectin on endothelial cells and adherent platelets. This interaction results in "rolling" of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell into the inflamed tissue. In 2000 it was reported that PSGL-1 can also be expressed on the surface of platelets, although at a substantially lower level than that seen on the surface of leukocytes.