PML Protein Recombinant Rabbit Monoclonal Antibody [PSH02-68] (HA721846)

UNIPROT #

P29590

PROTEIN NAME

PML Protein

SYNONYMS

Acure promyelocytic leukemia, inducer of antibody;MYL antibody;Pml antibody;PML_HUMAN antibody;PP8675 antibody;Probable transcription factor PML antibody;Promyelocytic leukemia antibody;Promyelocytic leukemia inducer of antibody;Promyelocytic leukemia protein antibody;Protein PML antibody;RING finger protein 71 antibody;RNF 71 antibody;RNF71 antibody;TRIM 19 antibody;Tripartite motif protein TRIM19 antibody;Tripartite motif-containing protein 19 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, PML body, nucleolus, Endoplasmic reticulum membrane, Early endosome membrane.

FUNCTION

Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin of the cell nucleus. These nuclear bodies are present in mammalian nuclei, at about 1 to 30 per cell nucleus. PML-NBs are known to have a number of regulatory cellular functions, including involvement in programmed cell death, genome stability, antiviral effects and controlling cell division. PML mutation or loss, and the subsequent dysregulation of these processes, has been implicated in a variety of cancers.