PINK1 Recombinant Mouse Monoclonal Antibody [PSH22-50] (HA601588)

UNIPROT #

Q9BXM7

PROTEIN NAME

PINK1

SYNONYMS

BRPK antibody;FLJ27236 antibody;mitochondrial antibody;PARK 6 antibody;PARK6 antibody;Phosphatase and Tensin Homolog antibody;PINK 1 antibody;PINK1 antibody;PINK1_HUMAN antibody;Protein kinase BRPK antibody;PTEN induced putative kinase 1 antibody;PTEN induced putative kinase protein 1 antibody;PTEN-induced putative kinase protein 1 antibody;Serine/threonine kinase PINK1 mitochondrial antibody;Serine/threonine protein kinase PINK1 mitochondrial antibody;Serine/threonine-protein kinase PINK1 antibody

SUBCELLULAR LOCATION

SwissProt: Q9BXM7 Human SwissProt: Q99MQ3 Mouse SwissProt: B5DFG1 Rat

FUNCTION

A member of the serine / threonine protein kinase family, PTEN induced putative kinase 1 (PINK1) is a tumor suppressor. PINK1 is primarily located in mitochondria, and is ubiquitously expressed in testis, skeletal muscle, and heart tissue. at lower levels in pancreas, ovary, brain, placenta, kidney, liver, prostate and small intestine. During cellular stress PINK1 protects against mitochondrial dysfunction by inducing phosphorylation mitochondrial proteins. PINK1 mutations may give rise to different autophosphorylation activity. Mutations in the PINK1 gene (PARK6) are associated with early onset Parkinson's disease, a recessive neurodegenerative disorder characterized by resting tremor, muscular rigidity, bradykinesia and postural instability. Parkinson's disease generally involves the presence of intraneuronal accumulations of aggregated proteins (Lewy bodies) in brain neurons.