Phospho-RPS6 (S240 + S244) Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PS00-65] (HA750684)

UNIPROT #

P62753

PROTEIN NAME

Phospho-RPS6 (S240 + S244)

SYNONYMS

40S ribosomal protein S6 antibody;Air8 antibody;NP33 antibody;Phosphoprotein NP33 antibody;Pp30 antibody;Ribosomal protein S6 antibody;RP S6 antibody;rps6 antibody;RS6 antibody;RS6_HUMAN antibody;S6 antibody;S6 Ribosomal Protein antibody

SUBCELLULAR LOCATION

Cytosol, Endoplasmic reticulum, Nucleus.

FUNCTION

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.