Phospho-Rb (S608) Recombinant Rabbit Monoclonal Antibody [PSH11-04] (HA723271)

UNIPROT #

P06400

PROTEIN NAME

Phospho-Rb (S608)

SYNONYMS

Exon 17 tumor GOS561 substitution mutation causes premature stop antibody;GOS563 exon 17 substitution mutation causes premature stop antibody;OSRC antibody;Osteosarcoma antibody;p105-Rb antibody;P105RB antibody;PP105 antibody;pp110 antibody;PPP1R130 antibody;pRb antibody;Prepro retinoblastoma associated protein antibody;Protein phosphatase 1 regulatory subunit 130 antibody;Rb antibody;RB transcriptional corepressor 1 antibody;RB_HUMAN antibody;RB1 antibody;RB1 gene antibody;Retinoblastoma 1 antibody;Retinoblastoma suspectibility protein antibody;Retinoblastoma-associated protein antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, inactivating it, and the cell cycle is allowed to progress. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomavirus, bind and inactivate pRb, this can lead to cancer. The RB gene may have been responsible for the evolution of multicellularity in several lineages of life including animals.