Phospho-ATR (T1989) Rabbit Polyclonal Antibody (HA500405)

UNIPROT #

Q13535

PROTEIN NAME

Phospho-ATR (T1989)

SYNONYMS

Ataxia telangiectasia and Rad3 related antibody;Ataxia telangiectasia and Rad3-related protein antibody;ATR antibody;ATR_HUMAN antibody;FCTCS antibody;FRAP Related Protein 1 antibody;FRAP-related protein 1 antibody;FRP1 antibody;MEC1 antibody;MEC1 mitosis entry checkpoint 1 homolog antibody;Protein kinase ATR antibody;RAC3 antibody;Rad3 related protein antibody;SCKL antibody;SCKL1 antibody;Serine/threonine protein kinase ATR antibody;Serine/threonine-protein kinase ATR antibody

SUBCELLULAR LOCATION

Nucleus, Chromosome.

FUNCTION

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex. Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling. Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.