Phospho-ACSL4 (T484) Rabbit Polyclonal Antibody (HA500600)

UNIPROT #

O60488

PROTEIN NAME

Phospho-ACSL4 (T484)

SYNONYMS

ACS 4 antibody;ACS4 antibody;ACSL 4 antibody;Acsl4 antibody;ACSL4_HUMAN antibody;acyl CoA synthetase 4 antibody;Acyl CoA synthetase long chain family member 4 antibody;FACL 4 antibody;FACL4 antibody;Fatty acid Coenzyme A ligase antibody;fatty acid Coenzyme A ligase long-chain 4 antibody;LACS 4 antibody;LACS4 antibody;Lignoceroyl CoA synthase antibody;Long chain 4 antibody;long chain acyl CoA synthetase 4 antibody;long chain fatty acid CoA ligase 4 antibody;long chain fatty acid Coenzyme A ligase 4 antibody;Long-chain acyl-CoA synthetase 4 antibody;Long-chain-fatty-acid--CoA ligase 4 antibody;MRX63 antibody;MRX68 antibody

SUBCELLULAR LOCATION

Peroxisome membrane, Mitochondrion outer membrane, Microsome membrane, Endoplasmic reticulum membrane, Cell membrane.

FUNCTION

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants.