PHGDH Recombinant Mouse Monoclonal Antibody - BSA and Azide free [A10H9-R] (HA610207)

UNIPROT #

O43175

PROTEIN NAME

PHGDH

SYNONYMS

3 PGDH antibody;3-PGDH antibody;3-phosphoglycerate dehydrogenase antibody;3PGDH antibody;D-3-phosphoglycerate dehydrogenase antibody;EC 1.1.1.95 antibody;Epididymis secretory protein Li 113 antibody;HEL S 113 antibody;NLS antibody;NLS1 antibody;PDG antibody;PGAD antibody;PGD antibody;PGDH antibody;PGDH3 antibody;Phgdh antibody;PHGDHD antibody;Phosphoglycerate dehydrogenase antibody;SERA antibody;SERA_HUMAN antibody

SUBCELLULAR LOCATION

Cytosol, extracellular exosome.

FUNCTION

3-Phosphoglycerate dehydrogenase catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the committed step in the phosphorylated pathway of L-serine biosynthesis. It is also essential in cysteine and glycine synthesis, which lie further downstream. This pathway represents the only way to synthesize serine in most organisms except plants, which uniquely possess multiple synthetic pathways. Nonetheless, the phosphorylated pathway that PHGDH participates in is still suspected to have an essential role in serine synthesis used in the developmental signaling of plants. Because of serine and glycine's role as neurotrophic factors in the developing brain, PHGDH has been shown to have high expression in glial and astrocyte cells during neural development.