PGP9.5 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JM10-59] (HA750375)

UNIPROT #

P09936

PROTEIN NAME

PGP9.5

SYNONYMS

Epididymis luminal protein 117 antibody;Epididymis secretory protein Li 53 antibody;HEL 117 antibody;HEL S 53 antibody;NDGOA antibody;Neuron cytoplasmic protein 9.5 antibody;OTTHUMP00000218137 antibody;OTTHUMP00000218139 antibody;OTTHUMP00000218140 antibody;OTTHUMP00000218141 antibody;Park 5 antibody;PARK5 antibody;PGP 9.5 antibody;PGP9.5 antibody;PGP95 antibody;Protein gene product 9.5 antibody;Ubiquitin C terminal esterase L1 antibody;Ubiquitin C terminal hydrolase antibody;Ubiquitin C terminal hydrolase L1 antibody;Ubiquitin carboxyl terminal esterase L1 antibody;Ubiquitin carboxyl terminal hydrolase isozyme L1 antibody;Ubiquitin carboxyl-terminal hydrolase isozyme L1 antibody;Ubiquitin thioesterase L1 antibody;Ubiquitin thiolesterase antibody;Ubiquitin thiolesterase L1 antibody;UCH-L1 antibody;UCHL1 antibody;UCHL1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C12 family.

TISSUE SPECIFICITY

Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated.

SUBCELLULAR LOCATION

Cytoplasm, Endoplasmic reticulum membrane.

FUNCTION

Ubiquitin carboxy-terminal hydrolase L1 (EC 3.1.2.15, ubiquitin C-terminal hydrolase, UCH-L1) is a deubiquitinating enzyme. UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is abundantly present in all neurons (accounts for 1-2% of total brain protein), expressed specifically in neurons and testis/ovary. The catalytic triad of UCH-L1 contains a cysteine at position 90, an aspartate at position 176, and a histidine at position 161 that are responsible for its hydrolase activity.