Periostin Recombinant Rabbit Monoclonal Antibody [PSH24-36] (HA724443)

UNIPROT #

Q62009

PROTEIN NAME

Periostin

SYNONYMS

Fasciclin-I like antibody;MGC119510 antibody;MGC119511 antibody;OSF 2 antibody;OSF-2 antibody;OSF2 antibody;Osteoblast specific factor 2 (fasciclin I like) antibody;Osteoblast specific factor 2 antibody;Osteoblast specific factor antibody;Osteoblast-specific factor 2 antibody;PDLPOSTN antibody;Periodontal ligament specific periostin antibody;Periostin antibody;Periostin isoform thy2 antibody;Periostin isoform thy4 antibody;Periostin isoform thy6 antibody;Periostin isoform thy8 antibody;Periostin osteoblast specific factor antibody;PN antibody;POSTN antibody;RP11 412K4.1 antibody

SUBCELLULAR LOCATION

Golgi apparatus, Secreted, extracellular space, extracellular matrix.

FUNCTION

Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a protein that in humans is encoded by the POSTN gene. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells. Periostin is a gla domain vitamin K dependent factor. Periostin is a secreted extracellular matrix protein that was originally identified in cells from the mesenchymal lineage (osteoblasts, osteoblast-derived cells, the periodontal ligament, and periosteum). It has been associated with the epithelial-mesenchymal transition in cancer and with the differentiation of mesenchyme in the developing heart. This protein shares a homology with fasciclin I, a secreted cell adhesion molecule found in insects.