PD1 Mouse Monoclonal Antibody (IRS191MS)

UNIPROT #

Q02242

PROTEIN NAME

PD1

SYNONYMS

CD279 antibody;CD279 antigen antibody;hPD 1 antibody;hPD l antibody;hPD-1 antibody;hSLE1 antibody;PD 1 antibody;PD-1 antibody;PD1 antibody;PDCD 1 antibody;PDCD1 antibody;PDCD1_HUMAN antibody;Programmed cell death 1 antibody;Programmed cell death 1 protein antibody;Programmed cell death protein 1 antibody;Protein PD 1 antibody;Protein PD-1 antibody;SLEB2 antibody;Systemic lupus erythematosus susceptibility 2 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Programmed cell death protein 1 (PD-1), (CD279 cluster of differentiation 279). PD-1 is a protein encoded in humans by the PDCD1 gene. PD-1 is a cell surface receptor on T cells and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells). PD-1 inhibitors, a new class of drugs that block PD-1, activate the immune system to attack tumors and are used to treat certain types of cancer. PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells. PD-1 binds two ligands, PD-L1 and PD-L2.